No guarantees since I'm not using Vista, but I believe it should run CS:Source perfectly. Lol!

Your Processor, RAM and Graphics card absolutely kick butt lol. Kicks my butt anyway.

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Running On....
AMD Phenom IIx4 945 3.0Ghz
ASUS M4A77TD Pro
G.Skill DDR3 1333 2*2GB
EVGA GTX 275 with 896MB
500GB HDD + 1TB HDD External
Cooler Master HAF922 case