Hi Neal,
I guess I got things in the wrong order here.
I did run AV and Spybot scans last night, prior to my post. I have just completed a malwarebytes scan. While the scan was in progress the AV went off a couple of times an said it had dealt with things by deletion.
MBAM turned up one item, which it removed at my request (found in system volume information an the E: drive, I use that drive for backups), the log follows:

Malwarebytes' Anti-Malware 1.38
Database version: 2335
Windows 5.1.2600 Service Pack 3

26/06/2009 10:33:33 AM
mbam-log-2009-06-26 (10-33-33).txt

Scan type: Full Scan (C:\|D:\|E:\|F:\|)
Objects scanned: 286385
Time elapsed: 1 hour(s), 21 minute(s), 10 second(s)

Memory Processes Infected: 0
Memory Modules Infected: 0
Registry Keys Infected: 0
Registry Values Infected: 0
Registry Data Items Infected: 0
Folders Infected: 0
Files Infected: 1

Memory Processes Infected:
(No malicious items detected)

Memory Modules Infected:
(No malicious items detected)

Registry Keys Infected:
(No malicious items detected)

Registry Values Infected:
(No malicious items detected)

Registry Data Items Infected:
(No malicious items detected)

Folders Infected:
(No malicious items detected)

Files Infected:
e:\system volume information\_restore{e004d452-2be5-4d3e-8a75-e9ee847ec264}\rp46\A0008209.exe (Backdoor.Bot) -> Quarantined and deleted successfully.

Sorry for not getting things in the right order, especially since I did read the appropriate sticky.
mbam asked for a restart and I obliged.