According to
this page, your motherboard will support a new graphics card just fine. Check your motherboard manual for procedures.
One thing you do need to worry about is power. Graphics cards can easily consume more power than your CPU. Use the
eXtreme PSU Calculator Lite to determine your power supply unit (PSU) requirements. Plug in all the hardware you think you might have in 2 or 3 years (extra drives, bigger or 2nd video card, more RAM, etc.). Be sure to read and heed the notes at the bottom. I recommend you set Capacitor Aging to 30%, and if you participate in distributive computing projects (e.g. BOINC or Folding@Home), I recommend setting TDP to 100%. Research your video card and pay particular attention to the power supply requirements for your card listed on your video card maker's website. Then look for power supply brands listed under the "Good" column of
PC Mechanic's PSU Reference List. Ensure the supplied amperage on the +12V rails of your chosen PSU meets the requirements of your video card. Don't try to save a few dollars by getting a cheap supply. Digital electronics, including CPUs, RAM, and today's advanced graphics cards, need clean, stable power. A good, well chosen supply will provide years of service and upgrade wiggle room. I strongly recommend you pick a supply with an efficiency rating equal to, or greater than 80%. Look for the
80 Plus - EnergyStar Compliant label. And don't forget to budget for a good UPS with AVR (automatic voltage regulation).