Totally. That is all I use.
First off don't buy any type of "kit". Buy the specific parts for your specific system.
It is very easy actually as long as you are comfortable taking the whole system apart.
Most blocks need to be connected thru the boards so you will have to remove the motherboard from the case.
No big deal once you've done it or do it.
You can put blocks on the CPU and the GPU and the Northbridge depending on your heat issues and what you are trying to accomplish.
Liquid cooling reduces temps by nearly 50% in most cases over stock fans.
I will post a couple links for you where this world will open up but please come back here and let us know how it's going.
http://forums.extremeoverclocking.co...play.php?f=181
You also might find my last experience interesting:
New build
As to a hardware source I recommend Swiftech from my experience:
http://www.swiftnets.com/
As to a great personal retailer:
http://www.sidewindercomputers.com/
The owner of this company actually exchanges e-mails with you to get things right. After too many press 1 ifs I found this service incredible.
Let us know if we can help more.